Avastin Said to Help Ovarian Cancer Patients

by , under Contemporary Cancer Topics, Ovarian Cancer

I came across a report that claims that the anticancer drug, Avastin, can help ovarian cancer patients.  The drug, which is commonly used to treat colon, breast and brain cancers, now may have an application in ovarian cancer.

Researchers added Avastin to a standard chemotherapy and maintenance regimen to a group of women with cancer of the ovaries or closely related areas. They found that the women who were given Avastin lived an average of four months longer without the disease progressing than those who did not receive it.

Avastin is not without a level of controversy in its history.  Some experts objected to FDA approval of it for metastatic breast cancer because the drug only slows tumor growth, but fails to extend survival.  The FDA approved it for use anyway, even though a panel of outside advisers voted 5 to 4 against approval.  Although Avastin reduces tumor size and shows an increase in progression-free survival time, it does not prolong or increase the quality of life for late-stage cancer patients.

Avastin is designed to retard the growth of tumor cells by blocking the growth of new blood vessels (angiogenesis).  It does this by blocking the production of vascular endothelial growth factor (VEGF-A).  Tumors usually require a huge amount of new blood vessels in order for them to grow and metastasize.

Unfortunately, Avastin may damage patients’ kidneys.  A study found that the treatment can cause a series of serious side effects, such as proteinuria, high blood pressure, higher risk of blood clots, elevated white blood cell counts, bleeding in the stomach and intestine, intestinal perforations and impaired healing ability.  Proteinuria is characterized by severe losses of protein in the urine that can possibly lead to kidney damage, kidney failure, and even death.

The price seems very steep for a drug that only prolongs life for about an average of approximately 5 months.  The price for a year of treatment with the drug can range from $42,000 to $100,000.  With prices like that, it would be reasonable to expect that it would be a cure.  Once again, the strategy is to treat the body as if it were an inert battlefield.  Powerful drugs like this, although they damage the cancer, they also greatly damage the body and its ability to heal and repair itself.

Although it is admirable that some progress is being made in treatments, unfortunately the same paradigm that has not created any cures for cancer are still being dogmatically retained by those who work for and with the Medical Establishment.  The only way that a true breakthrough in cancer treatment will be achieved is when a new, more rational paradigm is adopted.  Remember that Einstein said that a problem cannot be solved with the same level of thinking that created it.  The results from conventional cancer treatment can not produce any significantly better results until there is a significant change in the foundational concepts of our understanding of cancer and how to cure (not treat) it.

  1. Owen M.

    Starting a site relevant to yours forced me to get into some research and I found your post to be very helpful. My site is centered around the idea that you can starve cancer by stopping the angiogenic process. I wish you good luck with your work in the future and you can be sure I’ll be following it.

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