There is always a plethora of cancer stories in the press that speak of hope and promise for the ever-ending cascade of new drugs and various treatments. In fact, I’ve noticed that there has been a promising new drug, therapy, or treatment that will change things that is ‘just around the corner’ for as long as I can remember, which is over 30 years ago. What gives?
For example, I found an article about an experimental drug called PLX4032, which is said to reverse the effects of a gene mutation that is found in certain tumors. They say that it is a prototypical example of the new approach to cancer treatment. This is a strategy in which the cancer is targeted based on genotypes, and other various biomarkers of the cancer cell.
In some patients, the drug was said to have produced great results. But when this drug was given to patients with colorectal tumors with the same gene mutation, it failed miserably. This was a ‘flashing red light’ to me that strongly implies that the present paradigm is not correct, and is not working. continue reading…